AKSHAR ANALYTICAL LABORATORY & RESEARCH CENTRE
Liquid Cromatography Mass Spectroscopy (LC-MS)

Liquid Cromatography Mass Spectroscopy (LC-MS)

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Liquid Cromatography Mass Spectroscopy (LC-MS)

LC/MS is a hyphenated technique, combining the separation power of HPLC, with the detection power of mass spectrometry. Even with a very sophisticated MS instrument, HPLC is still useful to remove the interferences from the sample that would impact the ionization.

Closely related to LC/MS are some other techniques, like flow injection/MS, CE or CEC/MS, capillary LC or nano LC/MS In all cases, there is the need for an interface that will eliminate the solvent and generate gas phase ions, then transferred to the optics of the mass spectrometer.